Principal Investigator: Dr. Aneika Leney
Aneika obtained a BSc in Biochemistry at University of York, UK during which she spend a year in industry working for GlaxoSmithKline. Next she joined Sheena Radford and Alison Ashcroft’s lab in the Astbury Centre, University of Leeds, UK, where she completed her PhD in Biological Mass Spectrometry. Her research focussing on amyloid assembly, bacterial pilus assembly and the development of novel technologies to monitor membrane proteins.
After her studies, Aneika relocated to Canada whereby she joined the Alberta Glycomics centre as a post-doctoral researcher under the supervision of John Klassen. Following this, she moved to Utrecht University in the Netherlands where she took a senior post-doctoral role in the laboratory of Albert Heck in the Netherlands Proteomics Centre. Her research focusing on post-translational modifications and the role they have in modulating protein function.
In 2018, Aneika joined the School of Biosciences at the University of Birmingham to establish her own research group.
Sarah is a Biochemistry MSci student, undertaking her final year project in the Leney Lab. She did an industrial placement year at AstraZeneca, where she was using chromatographic, mass spectrometric and electrophoretic techniques to characterise drug stability. Now, her project investigates phycocyanin - a blue pigment protein, used as a food colourant in industry. Outside of the lab, Sarah enjoys attending music festivals and gigs, and going to the gym.
Matt is a PhD student with a Masters degree in Biochemistry from the University of York. He works with Professor Jo Morris and Dr Leney on BRCA1 and its role in breast cancer. DNA is often damaged and when this occurs proteins are recruited to help stabilize and repair the damage. However, frequently in cancer, the repair process does not occur effectively. Matt is aiming to better understand how these proteins are modified during the repair process and the implication that has in cancer. Matt spends most his free time watching TV and movies or goes to the pub with his mates.
Jedd gained an MSci in Natural Sciences (Chemistry and Biology) at the University of Nottingham, completing his 4th year project in the Neil Oldham group before continuing on to complete a PhD in biological mass spectrometry (BBSRC DTP). His research focussed on using mass spectrometry, particularly native, to investigate proteins involved in polyketide biosynthesis. Jedd has a keen interest in finding new ways to approach biological problems through mass spectrometry through combining several native mass spectrometry techniques and computational analysis.
Jedd joined the Leney group in October 2020 as a post-doctoral researcher. Among the oldest organisms on the planet, algae have evolved incredibly efficient mechanisms for harvesting light energy. Phycobilosomes, the ‘solar panels’ that make this possible, are complexes of coloured proteins, the exact composition/structure of which is unknown. Harnessing these mechanisms could pave the way for more efficient energy capture on the macro-scale. Jedd is studying these complexes using integrative and complementary mass spectrometry techniques, e.g. native, cross-linking, top-down and bottom-up.
When he is not doing mass spectrometry, Jedd spends time reading, playing music and home-brewing beer.
Nik is a MSci biochemistry student returning to University from an industrial placement at the Binding Site. He has experience using a range of chromatographic and electrophoretic techniques to develop new materials to test antibodies used in immunodiagnostic assays. His research project in the Leney lab involves investigating the binding interactions between the enzyme, Pin1, and phosphorylated peptide sequences from proteins implicated in the progression of Alzheimer’s Disease. Outside of his degree, Nik really enjoys rock climbing and generally being outdoors with friends.
Laura is a 3rd year biochemistry BSc student at the University of Birmingham. Her final year research project involves understanding post translational modifications (PTM) on proteins and how these different PTMs can affect each other. She is using mass spectrometry to identify PTMs in the cell. Outside of her degree, she is part of the University handball team and the dance society.
Arppana (Sarah) Varughese
Sarah is a third year MSci Biochemistry student currently studying at the University of Birmingham, where she is doing a research literature review project under the supervision of Dr Leney. The project is about post-translational modifications (PTM) of proteins, how this can be researched using mass spectrometry, and how studying this can be beneficial from a therapeutic viewpoint in particular. Outside her studies, Sarah's interests include playing the guitar, football, and travelling.
Kish Adoni is a PhD researcher under the supervision of Dr D. Cunningham, Prof J. Heath and Dr A. Leney. He graduated with an MSci in Natural Sciences (Chemistry and Biology) from Durham University before moving to the University of Birmingham. His PhD research uses proteomics mass spectrometry techniques to investigate the role of PTM’s in cell signalling pathways. Specifically, he is interested in the how aberrant signalling in various phospho-pathways lead to breast cancer, and the nodes of action within these cascades that can be targeted with tailored therapeutics. Away from the lab, Kish’s interests include sport, music and film.
Anna completed her Bsc in Biochemistry at the University of Birmingham before joining the Leney lab as an Msc Molecular Biotechnology student. Her project focuses on how mass spectrometry could be used to rapidly identify cyanobacteria species. This is important because cyanobacteria populations are increasing as a result of climate change, and therefore so are the quantities of harmful cyanotoxins which some species produce.
Monisa is doing her MRes project in the Leney lab. She joined us after completing her MSc. degree in Bioanalytical sciences. Her project focuses on the structure of the phycobilisome and its re-organization when exposed to different wavelengths of light'.
Alex is a final year MSci Biochemistry student doing her research project in the Leney lab. The project aims to characterise fluorescent proteins from red microalgae, known as phychobiliproteins. These proteins already have many biotechnological and commercial applications, but the complex structure that they form inside alage, called the phycobilisome, is not fully known. She is using a range of biophysical techniques, including FPLC and Mass Spectrometry to understand the composition of the Phycobilisome. Outside of the lab Alex enjoys playing squash and tennis.
Heather is an MChem graduate from the University of Warwick. Her research work there focused on determining the specificity of bacterial enzymes towards lignin metabolites using chromatographic assays. She is currently completing a 3 month research internship in the Leney lab as part of the Midlands Intergrative Biosciences Training Partnership PhD scheme. Her work in the lab focusing on using cross linking mass spectrometry to determine the structure of phycobilisomes extracted from the red algae Porphorydium cruentum.
Manjari is a 2nd year MSci Biochemistry student. She is performing a small research project alongside her studies. Her project focuses on using native mass spectrometry to monitor protein complexes and their interaction partners.